Nattokinase Plus
Nattokinase is an enzyme contained in the traditional Japanese food natto. The enzyme is produced by the bacterium “Bacillus subtilis” during the soybean fermentation process.
High natto consumption is associated with the Japanese population's longer average life expectancy and lower chronic disease rates. In particular, studies show that people with a diet rich in natto are less affected by heart disease and its complications.
The health benefits of natto are thanks to this unique enzyme. When soybeans are fermented, the bacteria used activate nattokinase, giving the food its cheesy appearance, taste and a range of scientifically proven health benefits.
Natto has been popular in East Asia for thousands of years.
We offer nattokinase as a dietary supplement.
Why Vitamine D3 as Supplement?
Vitamin D3 as a supplement is used to strengthen the immune system.
An interesting aspect is that vitamin D3 can have a positive influence on multiple sclerosis (MS).
The further north or south you go from the equator, the more MS diseases occur. Sunlight produces vitamin D3 in the body. The further north or south you live from the equator, the less vitamin D3 your body produces. But if you just take vitamin D3 as a supplement, it doesn't work. It only works if you take D3 together with vitamin K2 in MK7 quality - and that is nattokinase.
It is well known that patients with a vitamin D deficiency are more likely to have cardiovascular problems (e.g. heart attack,
Stroke), are tired more often in everyday life, show symptoms of weakness and have a weakened immune system. (Source: Karin Amrein, MD et al.,Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency: The VITdAL-ICU Randomized Clinical Trial )
In recent years, three meta-analyses of clinical studies have come to the conclusion that vitamin D supplementation was associated with a reduction in the death rate from cancer by around 13 percent. Scientists at the German Cancer Research Center (DKFZ) now applied these results to the situation in Germany and calculated: If all Germans over 50 years of age were given a Vitamin D-Supplementation, up to 30,000 cancer deaths per year could potentially be avoided and more than 300,000 years of life could be gained.
N. Keum und D. H. Lee et al. were able to show in a meta-analysis of various clinical studies that nutritional supplementation with vitamin D leads to a significantly reduced cancer mortality.
Health Benefits:
Nattokinase has positive effects on your health, including:
- Lower risk of heart disease
Studies show that nattokinase dissolves blood clots - which helps maintain good blood vessel structure,
improves blood circulation and reduces the risk of heart disease. Nattokinase can also help lower blood pressure and thus reduce the strain on the heart, which can lead to heart attacks or strokes.
- Improved sinus condition
Chronic sinusitis is a persistent inflammation of the sinuses that can be caused by allergies, bacteria, fungal infections or even asthma. It is one of the most common chronic diseases in adults. In some cases, people with chronic sinusitis need surgery to clear the nasal passages.
Research shows that nattokinase can shrink obstructing nasal polyps and thin mucus, improving air circulation and relieving discomfort. Because of these effects, scientists continue to study the enzyme as a treatment for symptoms of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and bronchitis.
- Improved metabolism and gut health
Nattokinase can promote the balance of bacteria in our gut, also known as our microbiome. Poor gut health can weaken the immune system and increase the risk of many chronic diseases such as diabetes, obesity, rheumatoid arthritis, cancer and heart disease.
Nattokinase's probiotic properties can also boost metabolism and reduce body fat, thereby regulating and potentially preventing metabolic disorders such as obesity and diabetes.
Possible risks and side effects
Nattokinase is generally safe, but the enzyme's powerful effects can cause complications in people with certain health problems. Speak to your naturopath before adding Nattokinase Plus to your diet to ensure you do not experience any of the following health risks:
Interactions with other medications
If you take nattokinase with certain medicines, excessive bleeding may occur. Because nattokinase can dissolve blood clots, people taking blood-thinning medications may be at higher risk of bleeding.
Doctors often also recommend taking aspirin daily for people who are at risk of a heart attack or stroke. However, taking nattokinase can increase the effects of aspirin, which can lead to unexpectedly heavy bleeding.
Nattokinase may also help lower your blood pressure. If you have low blood pressure or are taking antihypertensive medication, be sure to speak to your naturopath/naturopath before taking nattokinase.
Deep vein thrombosis
Although nattokinase's ability to combat blood clots may prevent deep vein thrombosis, it should not be used as a treatment without naturopathic medical supervision. Nattokinase could theoretically dislodge a clot, which could lead to complications.
Pregnancy
There is not enough research to indicate that nattokinase is safe for pregnant or breastfeeding women.
Amounts and dosage
There is no firm recommendation for nattokinase, but studies suggest that an oral dose of 100 to 400 milligrams per day provides health benefits.
Clinical experiences
In 2018, Hongjie Chen et al. in one study over a promising alternative in the prevention and treatment of cardiovascular diseases.
"Cardiovascular diseases (CVD: C Ardio v ascular D esease) are the leading cause of death worldwide and our approach to control and treat CVD mortality is limited. Nattokinase (NK), the most active ingredient in Natto, has a variety of beneficial cardiovascular effects. Natto consumption has been associated with a reduction in CVD mortality. Recent research has shown that NK has strong fibrinolytic activity, antihypertensive, anti-atherosclerotic, as well as lipid-lowering, antiplatelet and neuroprotective effects. In the review of this study, the main pharmacological effects of NK are discussed, with an emphasis on its clinical relevance to cardiovascular disease. It describes the advantages of NK and the outstanding questions related to the pharmacokinetics of NK. The available evidence suggests that NK is a unique natural compound that possesses several important cardiovascular beneficial effects for patients with cardiovascular disease and is therefore an ideal drug candidate for the prevention and treatment of cardiovascular disease. Nattokinase is a promising alternative in the treatment of cardiovascular diseases."
Takashi Tanikawa et al. report in August 2022 in their study on the degradative effect of nattokinase on the spike protein
of SARS-CoV-2.
"Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developed into a pandemic and has caused enormous damage to people's lives and economies in many countries around the world. However Therapeutics against SARS-CoV-2 remain unclear. SARS-CoV-2 has a spike protein (S protein), whereby cleavage of the S protein is essential for virus entry. Nattokinase is produced and effective by Bacillus subtilis var has a positive effect on human health. This study examines the effect of nattokinase on the S protein of SARS-CoV-2. When cell lysates transfected with S protein were incubated with nattokinase, the S protein became dose and time dependent degraded. Immunofluorescence analysis showed that the S protein on the cell surface was degraded when nattokinase was added to the culture medium. Our results therefore suggest that nattokinase has the potential to inhibit SARS-CoV-2 infection through S protein degradation having."
Hongjie Chen et al. showed in one study with more than 1000 participants the effective treatment of the progression of atherosclerosis and hyperlipidemia with nattokinase.
"Nattokinase (NK), known as a potent fibrinolytic and antithrombotic agent, has been shown to have anti-atherosclerotic and lipid-lowering effects. However, there are limited human clinical trial data. In this clinical trial involving 1,062 participants, our aim was to evaluate the effectiveness of To investigate NK in atherosclerosis and hyperlipidemia and safety at a dose of 10,800 FU/day after 12 months of oral administration. Various factors, including lower doses, affecting the pharmacological effects of NK were also investigated. We found that NK in a dose of 10,800 FU/day effectively managed the progression of atherosclerosis and hyperlipidemia and significantly improved the lipid profile. Significant reductions in carotid intima-media thickness and carotid plaque size were observed. Improvement rates ranged from 66.5% to 95.4%.At a dose of 3,600 FU/day, NK was found to be ineffective in lowering lipids and suppressing the progression of atherosclerosis. The lipid-lowering effect of NK was more pronounced in subjects who smoked, drank alcohol and in subjects with a higher BMI. Regular exercise further improved the effect of NK. Co-administration of vitamin K2 and aspirin with NK produced a synergistic effect. No significant side effects associated with the use of NK have been identified. In conclusion, our data show that atherosclerosis progression and hyperlipidemia can be effectively treated with NK at a dose of 10,800 FU/day. The lower dose of 3,600 FU per day is ineffective. The dose of 10,800 FU/day is safe and well tolerated. Some lifestyle factors and the simultaneous administration of vitamin K2 and aspirin lead to improved results when using NK. Our results provide clinical evidence for the effective dose of NK in the treatment of cardiovascular disease and challenge the recommended dose of 2,000 FU per day."